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Updated: Oct 29, 2025

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

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Socioeconomic impacts on the intergenerational associations of preterm birth

Dong Liu1,2, Ge Lin3, Ming Qu2

  • 1University of Nebraska Medical Center, Omaha, NE, USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|July 6, 2021
PubMed

Insights

Mothers born preterm face a higher risk of preterm birth (PTB) recurrence, particularly in disadvantaged neighborhoods. Improving socioeconomic status through residential mobility can significantly reduce this risk.

Area of Science:

  • Reproductive Health
  • Perinatal Epidemiology
  • Social Determinants of Health

Background:

  • Intergenerational transmission of preterm birth (PTB) risks is not well understood.
  • Socioeconomic status (SES) likely plays a role in PTB recurrence.
  • Investigating SES impact on PTB is crucial for public health interventions.

Purpose of the Study:

  • To assess the intergenerational impact of socioeconomic status on preterm birth.
  • To determine if maternal history of PTB influences offspring PTB risk.
  • To explore the role of neighborhood poverty and residential mobility in PTB recurrence.

Main Methods:

  • Retrospective cohort study of singleton female births in Nebraska (1995-2005).
  • Follow-up data linkage of mothers and their subsequent infants (2009-2019).
  • Generalized estimating equations used to analyze PTB risk factors, controlling for covariates.

Main Results:

  • Mothers with a history of PTB were 37% more likely to have a PTB infant.
  • This risk increased significantly in neighborhoods with high poverty (OR 1.56).
  • Relocation from a poor to a well-off neighborhood was protective (OR 0.47).

Conclusions:

  • Maternal history of preterm birth is a significant risk factor for offspring PTB.
  • Neighborhood socioeconomic disadvantage exacerbates PTB risk.
  • Upward social mobility, indicated by residential moves to better neighborhoods, acts as a protective factor against PTB recurrence.
Abstract

Keywords:
Preterm birthgeneticsintergenerationalneighborhoodsocial mobility

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