Bronchopulmonary dysplasia in extremely premature infant with congenital lobar emphysema: a case report
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Updated: Oct 29, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Bingchun Lin1, Huitao Li1, Chuanzhong Yang2
1Department of Neonatology, Shenzhen Maternity & Child Healthcare Hospital, Cheeloo College of Medicine, Shandong University, Shenzhen, Guangdong, China.
Insights
Congenital lobar emphysema (CLE) is a rare lung condition in premature infants. Early detection with CT scans and prompt surgery are crucial for managing this severe respiratory condition.
Area of Science:
- Pediatric Pulmonology
- Neonatology
- Thoracic Surgery
Background:
- Congenital lobar emphysema (CLE) is a cystic lung disease causing lobe overinflation and surrounding compression.
- Symptomatic CLE often necessitates urgent surgical intervention.
- CLE requires vigilance in extremely premature infants with bronchopulmonary dysplasia (BPD) exhibiting localized emphysema on chest X-rays.
Observation:
- A case report details a premature infant (27 weeks + 4 days gestational age) presenting with severe respiratory distress at 60 days old.
- Chest imaging revealed right middle lobe emphysema, confirmed as CLE via histopathology.
- This highlights a potential complication in high-risk premature infants.
Findings:
- Premature infants, particularly those with BPD, are at risk for CLE.
- Localized emphysema on imaging in this population warrants high suspicion for CLE.
- Histopathological examination confirmed the diagnosis.
Implications:
- Early recognition of CLE in extremely premature infants is critical.
- Pulmonary CT scans are essential for timely diagnosis.
- Prompt surgical intervention can prevent delayed treatment and improve outcomes for infants with CLE.
Background:
Congenital lobar emphysema (CLE) is a congenital pulmonary cystic disease, characterized by overinflation of the pulmonary lobe and compression of the surrounding areas. Most patients with symptoms need an urgent surgical intervention. Caution and alertness for CLE is required in cases of local emphysema on chest X-ray images of extremely premature infants with bronchopulmonary dysplasia (BPD).
Case Presentation:
Here, we report a case of premature infant with 27 + 4 weeks of gestational age who suddenly presented with severe respiratory distress at 60 days after birth. Chest X-ray and computed tomography (CT) indicated emphysema in the middle lobe of the right lung. The diagnosis of CLE was confirmed by histopathological examinations.
Conclusions:
Although extremely premature infants have high-risk factors of bronchopulmonary dysplasia due to their small gestational age, alertness for CLE is necessary if local emphysema is present. Timely pulmonary CT scan and surgical interventions should be performed to avoid the delay of the diagnosis and treatment.
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