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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Oct 29, 2025

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Understanding protection from SARS-CoV-2 using metabolomics.

Elettra Barberis^1,2, Elia Amede^1,2, Matteo Tavecchia^1,2

¹Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Scientific Reports

|July 6, 2021

Summary

Higher levels of monolaurin may protect against COVID-19, while elevated cholesterol increases risk. Metabolomics can identify individuals at risk and inform personalized health strategies against SARS-CoV-2.

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Last Updated: Oct 29, 2025

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

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Published on: May 27, 2014

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Published on: November 29, 2024

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Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

Area of Science:

Metabolomics
Infectious Disease Epidemiology
Nutritional Science

Background:

The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a global health threat.
Vaccination efforts are ongoing, but herd immunity remains elusive, necessitating strategies to identify at-risk individuals and protective measures.
There is a critical need to understand host factors, including metabolic profiles, that influence susceptibility and severity of COVID-19.

Purpose of the Study:

To investigate metabolic phenotypes associated with protection from or predisposition to SARS-CoV-2 infection.
To identify potential biomarkers for COVID-19 risk stratification.
To explore the role of nutraceuticals in mitigating infection risk or disease severity.

Main Methods:

Untargeted metabolomics analysis of serum samples from 51 healthcare workers exposed to SARS-CoV-2.
Clinical follow-up to determine COVID-19 development within three weeks of blood collection.
Statistical analysis to identify metabolic signatures differentiating protected individuals from those who developed COVID-19.

Main Results:

A distinct metabolic signature was identified in individuals protected from SARS-CoV-2 infection.
Higher levels of circulating monolaurin, an antiviral compound, were observed in protected subjects.
Elevated cholesterol levels were associated with an increased risk of developing COVID-19.

Conclusions:

Monolaurin may play a protective role against SARS-CoV-2 infection, suggesting potential benefits from dietary supplements.
Higher cholesterol levels are a risk factor for developing COVID-19.
Metabolomics offers a valuable tool for personalized medicine and public health strategies in managing infectious diseases like COVID-19.