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Updated: Oct 29, 2025

Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
Published on: September 26, 2025
Modeling of Covid-19 trade measures on essential products: a multiproduct, multicountry spatial price equilibrium
Anna Nagurney1, Mojtaba Salarpour1, June Dong2
1Department of Operations and Information Management Isenberg School of Management University of Massachusetts Amherst Amherst MA USA.
Abstract:
In this paper, we develop a unified variational inequality framework in the context of spatial price network equilibrium problems that handles multiple products with multiple demand and supply markets in multiple countries as well as multiple transportation routes. The model incorporates a plethora of distinct trade measures, which is particularly important in the pandemic, as PPEs and other essential products are in high demand, but short in supply globally. In the model, product flows as well as prices at the supply markets and the demand markets in different countries are variables that allows us to seamlessly introduce various trade measures, including tariffs, quotas, as well as price floors and ceilings. Qualitative properties are analyzed. Numerical examples are provided to illustrate the impacts of the trade measures on equilibrium product path and link flows, and on prices, and demand and supply quantities. Given the relevance of the trade measures in the world today and discussions concerning the impacts, the framework constructed in this paper is especially timely.
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