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Related Concept Videos

Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Related Experiment Video

Updated: Oct 29, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

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Lessons learnt from COVID-19 coagulopathy.

Jecko Thachil1

  • 1Department of Haematology Manchester University Hospitals Manchester UK.

Ejhaem
|July 6, 2021
PubMed
Summary
This summary is machine-generated.

COVID-19 coagulopathy highlights the need for better understanding of blood clotting disorders. Future research should focus on specific markers and funding for hemostasis and thrombosis studies.

Keywords:
COVID‐19D‐dimercoagulopathyfibrinogenplateletsthrombocytopenia

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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Microfluidics in Assessing Platelet Function
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Area of Science:

  • Hematology
  • Infectious Diseases
  • Pathology

Background:

  • The COVID-19 pandemic revealed significant challenges in managing infectious diseases.
  • Coagulopathy emerged as a common complication during the pandemic, necessitating a deeper understanding.

Purpose of the Study:

  • To summarize lessons learned from COVID-19-associated coagulopathy.
  • To propose future clinical and research strategies for managing bleeding and clotting disorders.

Main Methods:

  • Review of early pandemic observations on COVID-19 coagulopathy.
  • Synthesis of clinical and research perspectives on hemostasis and thrombosis.

Main Results:

  • COVID-19 coagulopathy underscores the importance of differentiating local versus systemic clotting.
  • Effective use of D-dimers and identification of platelet activation markers are crucial.
  • Re-evaluation of fibrinogen's role, lupus anticoagulant, heparin-induced thrombocytopenia, and disseminated intravascular coagulation is needed.

Conclusions:

  • Further research and funding are essential for advancing hemostasis and thrombosis understanding.
  • Clinical strategies for managing COVID-19-related coagulopathy require refinement based on new insights.