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Updated: Oct 29, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Mechanical characterization of 3D printed mimic of human artery affected by atherosclerotic plaque through numerical
Daniele Guarnera1, Erasmo Carrera2, Christopher J Hansen3
1The BioRobotics Institute - Scuola Superiore Sant'Anna, Pisa, Italy.
Abstract:
This paper proposes a novel experimental investigation based on 3D printing to validate numerical models for biomechanics simulations. Soft elastomeric materials have been used in Polyjet multi-material 3D printer to mimicking arteries affected by atherosclerotic plaque. The nonlinear mechanical properties of five digital materials are characterized and used as an input for finite element (FE) modeling. Pressurized air is applied to the internal cavity of the printed model to reproduce the internal blood pressure in the artery. Digital Imaging Correlation is adopted to measure the displacement and deformation. A 1D linear higher-order FE model based on the Carrera Unified Formulation is compared to 3D nonlinear FE solutions.
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