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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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Long non-coding RNAs and microorganism-associated cancers.
Reza Ranjbar1, Mojtaba Behjatfar2, Ali Teimouri3
1Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Cell Biochemistry and Function
|July 6, 2021
Summary
Microorganisms can trigger cancer by altering gene expression through long noncoding RNAs (lncRNAs). This study explores the role of lncRNAs in microorganism-mediated cancers, revealing a novel mechanism in cancer development.
Area of Science:
- Molecular Biology
- Oncology
- Microbiology
Background:
- Cancer arises from abnormal cell growth driven by dysregulated signaling pathways.
- Gene expression, crucial for normal cellular function, is tightly regulated by factors including noncoding RNAs.
- Microorganisms are increasingly implicated in cancer development by potentially manipulating host cell regulatory mechanisms.
Purpose of the Study:
- To investigate the involvement of long noncoding RNAs (lncRNAs) in cancers induced by microorganisms.
- To elucidate the mechanisms by which microbial agents may influence host lncRNA expression and contribute to malignancy.
Main Methods:
- This study reviews existing literature and research on the interplay between microorganisms, lncRNAs, and cancer.
- Analysis of molecular pathways affected by microbial manipulation of lncRNA expression.
Main Results:
- Long noncoding RNAs (lncRNAs) are identified as key mediators in microorganism-induced cancers.
- Microorganisms can exploit or alter lncRNA functions to promote uncontrolled cell proliferation and oncogenesis.
Conclusions:
- Long noncoding RNAs play a significant role in the pathogenesis of microorganism-mediated cancers.
- Targeting microbial-modulated lncRNAs presents a potential therapeutic strategy for specific cancer types.
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