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Spirometry reference equations for children from a Middle Eastern population

Walid Al-Qerem1

  • 1Faculty of Pharmacy, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.

International Journal of Clinical Practice
|July 6, 2021
PubMed

Insights

New spirometry reference equations were developed for Middle Eastern children, improving lung function assessment. These customized equations are more accurate than global standards for this population.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Biostatistics

Background:

  • Spirometry is crucial for assessing pediatric lung function.
  • Existing spirometric reference equations lack universal applicability, particularly for Middle Eastern children.
  • Individual characteristics necessitate tailored reference values.

Purpose of the Study:

  • To develop specific spirometric reference equations for Middle Eastern children.
  • To enhance the accuracy of lung function assessments in the region.
  • To provide equations applicable to similar populations.

Main Methods:

  • Collected spirometric data from 1576 Jordanian children (ages 6-17).
  • Utilized generalized additive models to formulate customized reference equations.
  • Compared newly derived equations with Global Lung Initiative 2012 (GLI-2012) predictions.

Main Results:

  • New equations demonstrated superior suitability for Middle Eastern children compared to GLI-2012.
  • GLI-2012 equation accuracy varied across different age groups.
  • Z-score assessments confirmed the improved performance of the new equations.

Conclusions:

  • Formulated novel spirometric reference equations tailored for Middle Eastern children.
  • These equations can enhance the diagnosis and management of pediatric respiratory diseases.
  • Provides a more accurate tool for lung function evaluation in the region.
Abstract

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