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Published on: June 10, 2025
328
Association between prediabetes and adverse outcomes in heart failure
Linlin Mai1, Weixing Wen1, Min Qiu1
1Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China.
Diabetes, Obesity & Metabolism
|July 6, 2021
Summary
Prediabetes significantly increases the risk of mortality and adverse cardiac events in heart failure (HF) patients. Early risk stratification and targeted treatments are crucial for improving outcomes in this vulnerable population.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Diabetes mellitus is linked to worse outcomes in heart failure (HF) patients.
- The prognostic impact of prediabetes in HF remains unclear.
- This meta-analysis investigates prediabetes' association with mortality and adverse cardiac events in HF.
Purpose of the Study:
- To determine the risk of all-cause mortality in HF patients with prediabetes.
- To assess the association between prediabetes and adverse cardiac outcomes in HF.
- To synthesize evidence on prediabetes' prognostic impact in heart failure.
Main Methods:
- Systematic literature search of PubMed, Embase, and Google Scholar up to March 2021.
- Inclusion of 12 studies with 28,643 HF patients reporting adjusted risks.
- Random-effects models used to calculate pooled hazard ratios (HRs) and 95% confidence intervals (CIs).
Main Results:
- Prediabetes prevalence in HF patients ranged from 9.6% to 37.2%.
- Prediabetes was associated with increased all-cause mortality (HR 1.29) and cardiovascular mortality (HR 1.59).
- Increased risk observed for HF hospitalization (HR 1.33) and combined outcomes.
Conclusions:
- Prediabetes is linked to a worse prognosis in heart failure patients.
- Further research on risk stratification for HF patients with prediabetes is warranted.
- Effective treatment strategies are needed to improve outcomes for HF patients with prediabetes.
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