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Updated: Oct 29, 2025

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair
10:30

Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair

Published on: May 23, 2014

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Single-Stage Treatment of Fracture-related Infections

Olivia M Rice1, Kevin D Phelps1, Rachel Seymour1

  • 1Department of Orthopaedic Surgery, Atrium Health Musculoskeletal Institute, Charlotte, NC.

Journal of Orthopaedic Trauma
|July 6, 2021
PubMed
Abstract

Insights

This study presents a low-cost method for fabricating antibiotic-coated intramedullary nails in the operating room. This single-stage approach offers a promising alternative for treating fracture-related infections (FRIs) and septic nonunions.

Area of Science:

  • Orthopedic surgery
  • Infectious disease management
  • Biomaterials science

Background:

  • Fracture-related infections (FRIs) pose a significant clinical challenge.
  • Current staged treatments for FRIs involve multiple procedures, leading to increased patient morbidity and economic burden.
  • Single-stage treatment options for FRIs are being explored.

Purpose of the Study:

  • To detail the fabrication of low-cost, antibiotic-coated locked intramedullary nails within the operating room.
  • To present preliminary results of using this technique for acute FRIs and septic nonunions.

Main Methods:

  • Intraoperative fabrication of antibiotic-coated locked intramedullary nails.
  • Application of the fabricated nails for acute fracture-related infections.
  • Application of the fabricated nails for septic nonunion treatment.

Main Results:

  • Demonstration of a feasible low-cost method for antibiotic-coated nail fabrication.
  • Preliminary positive outcomes in treating acute FRIs.
  • Preliminary positive outcomes in treating septic nonunions.

Conclusions:

  • Intraoperative fabrication of antibiotic-coated locked intramedullary nails is a viable and potentially cost-effective strategy.
  • This single-stage approach may reduce morbidity associated with traditional staged treatments for FRIs.
  • Further investigation is warranted to confirm long-term efficacy and broader applicability.

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