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Updated: Oct 29, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

A cross-sectional study exploring cognitive impairment in kidney failure.

Pauline Nicholas^1,2, Theresa Green^3,4, Louise Purtell^1,5,6

¹Kidney Health Service, Metro North Hospital and Health Service, Brisbane, Australia.

Journal of Renal Care

|July 6, 2021

Summary

Cognitive impairment affects 34% of people with kidney failure, with higher rates in advanced stages. Factors like age, diabetes, and hypertension are associated with this condition, impacting decision-making.

Keywords:

Montreal Cognitive Assessment cognitive impairment end stage kidney disease kidney failure kidney replacement therapy

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Last Updated: Oct 29, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Published on: June 16, 2014

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Area of Science:

Nephrology
Neuroscience
Public Health

Background:

Cognitive impairment prevalence and factors in kidney failure are poorly understood.
Cognitive assessment is crucial for patient understanding and decision-making regarding treatment.

Purpose of the Study:

To determine the prevalence of cognitive impairment in individuals with kidney failure.
To identify factors associated with cognitive impairment in this population.

Main Methods:

A prospective cross-sectional study involving 222 participants with chronic kidney disease grade 5 (CKD G5).
Cognitive function assessed using the Montreal Cognitive Assessment (MoCA).
Data on demographics, anxiety, depression, kidney disease type, and comorbidities were collected.

Main Results:

The prevalence of cognitive impairment was 34%, significantly higher in CKD G5 patients.
Associated factors included older age, diabetes, hypertension, lower education, and specific biomarkers (hemoglobin, albumin, parathyroid hormone).
Longer duration of treatment also correlated with cognitive impairment.

Conclusions:

Cognitive impairment is common in kidney failure, affecting informed decision-making and treatment choices.
Routine cognitive function assessment should be integrated into clinical practice for kidney failure patients.