Oxyphil cells in primary hyperparathyroidism: a clinicopathological study
Ángela De la Hoz Rodríguez1,2,3, José Luis Muñoz De Nova4,5,6, Patricia Muñoz Hernández7
1General Surgery Department, Hospital Universitario de La Princesa, C/Diego de Leon 62, 4th Floor, 28006, Madrid, Spain.
Hormones (Athens, Greece)
|July 6, 2021
Summary
High oxyphil cell (OxC) content in parathyroid glands doesn't affect calcium levels in primary hyperparathyroidism (PHPT). However, it may indicate pathologic glands and worsen kidney function.
Area of Science:
- Endocrinology
- Pathology
- Nephrology
Background:
- The role of oxyphil cells (OxC) in primary hyperparathyroidism (PHPT) is debated, with historical views considering them involuted but potential roles in hormone secretion suggested.
- Clinical characteristics of OxC-rich adenomas and localization tests in PHPT require further investigation.
Purpose of the Study:
- To analyze the implications of oxyphil cell content in parathyroid glands of patients with primary hyperparathyroidism.
Main Methods:
- A retrospective cohort study included 238 patients undergoing parathyroidectomy for PHPT and normal glands.
- Researchers performed semi-quantitative analysis of oxyphil cell percentage, comparing groups with <25% OxC and >75% OxC.
Main Results:
- Patients with >75% OxC parathyroid adenomas (OxCA) showed worse preoperative glomerular filtration rate (p=0.043).
- Ultrasound accuracy for localization was lower in the high OxC group (48.3% vs. 73.7%; p=0.035).
- No normal parathyroid glands exhibited >75% OxC content.
Conclusions:
- High oxyphil cell content in parathyroid glands does not influence phosphocalcic metabolism in PHPT.
- Elevated OxC content appears exclusive to pathologic parathyroid glands and may correlate with renal function decline in PHPT patients.
