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Doxycycline-induced cholestatic liver injury
Sanskriti Varma1, John Nathanson2, Mitra Dowlatshahi3
1Department of Medicine, Columbia University Irving Medical Center, 622 West 168th Street, New York, NY, 10032, USA. sav9046@nyp.org.
Clinical Journal of Gastroenterology
|July 6, 2021
Summary
Doxycycline can cause rare, temporary liver injury, often presenting as cholestatic or mixed patterns. Promptly stopping doxycycline and monitoring is crucial for managing this adverse drug reaction.
Area of Science:
- Hepatology
- Pharmacology
- Toxicology
Background:
- Doxycycline-induced liver injury (DILI) is an uncommon adverse drug reaction.
- The clinical presentation and underlying mechanisms of DILI are not fully understood.
- DILI can manifest acutely or subacutely with varying patterns of liver enzyme elevation.
Observation:
- A case of cholestatic liver injury is presented in a middle-aged woman following doxycycline administration.
- The patient experienced a cholestatic pattern of liver injury.
- The injury resolved after discontinuation of the drug.
Findings:
- Doxycycline is a potential cause of drug-induced liver injury.
- Cholestatic liver injury is a possible manifestation of DILI.
- The duration of DILI can extend for several weeks.
Implications:
- Clinicians should consider doxycycline as a potential cause of liver injury in patients with relevant exposure history.
- Early recognition and withdrawal of doxycycline are essential for patient recovery.
- Further research into the pathogenesis of DILI is warranted to improve patient outcomes.
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