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Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Oct 29, 2025

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
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Evidence-Based Clinical Practice Guideline: Reconstruction after Skin Cancer Resection.

Andrew Chen1,2, John G Albertini1,2, Jeremy S Bordeaux1,2

  • 1Farmington, Conn.; Winston-Salem, Durham, and Gastonia, N.C.; Cleveland, Ohio; Walnut Creek, Irvine, and Sacramento, Calif.; Arlington Heights and Chicago, Ill.; Chantilly, Va.; Washington, D.C.; St. Augustine, West Palm Beach, Tampa, and Orlando, Fla.; Philadelphia and Hershey, Pa.; Marlton, N.J.; Indianapolis, Ind.; Iowa City, Iowa; and New York, N.Y.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|July 6, 2021
PubMed
Summary
This summary is machine-generated.

This study developed evidence-based guidelines for skin cancer reconstruction, focusing on common elements to improve patient care. Further research is needed due to limited high-level evidence for some recommendations.

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Area of Science:

  • Dermatology
  • Plastic Surgery
  • Evidence-Based Medicine

Background:

  • Skin cancer reconstruction involves diverse techniques and clinical scenarios.
  • Standardized guidelines are needed to optimize patient outcomes.
  • A multi-disciplinary approach is essential for comprehensive management.

Purpose of the Study:

  • To develop evidence-based guidelines for reconstruction after skin cancer resection.
  • To identify common elements and areas of consensus in reconstructive procedures.
  • To improve patient care through standardized recommendations.

Main Methods:

  • Convened a multi-disciplinary work group with diverse stakeholder representation.
  • Conducted a systematic literature review to identify relevant scientific research.
  • Utilized the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology for quality appraisal.

Main Results:

  • Developed recommendations on reconstruction timing, anticoagulation management, antibiotic use, pain control, and follow-up.
  • Distinguished between office-based and facility-based treatment options where applicable.
  • Identified areas where evidence was insufficient for high-level recommendations.

Conclusions:

  • The guidelines provide a framework for managing skin cancer reconstruction.
  • There is a significant need for more methodologically robust studies in this field.
  • Further research will help refine clinical practice and enhance patient care.