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Updated: Oct 29, 2025
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Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
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Lacosamide as first add-on or conversion monotherapy: A retrospective real-life study
Sara Casciato1, Pier Paolo Quarato1, Alessandro Gialluisi1
1IRCCS Neuromed, Pozzilli, IS, Italy.
Epilepsy & Behavior : E&B
|July 6, 2021
Summary
Lacosamide (LCM) effectively treats focal epilepsy as a first add-on or monotherapy. This study found LCM well-tolerated with high seizure freedom rates in adults.
Area of Science:
- Neurology
- Pharmacology
Background:
- Lacosamide (LCM) is an antiseizure medication with a novel mechanism.
- Approved for adjunctive therapy in focal onset and focal to bilateral tonic-clonic seizures.
Purpose of the Study:
- To evaluate the effectiveness and tolerability of LCM.
- Assessed LCM as first add-on or conversion monotherapy in adult focal epilepsy patients.
Main Methods:
- Retrospective study of 101 adult epilepsy patients.
- Data collected at 3, 6, and 12 months post-LCM initiation.
- Assessed retention rate, seizure freedom, and adverse events.
Main Results:
- 72% of patients retained LCM at 12 months.
- 54% achieved seizure freedom, with 44% on monotherapy.
- Mild adverse events like drowsiness and dizziness reported in 10%.
Conclusions:
- Lacosamide is an effective and well-tolerated treatment for focal epilepsy.
- Confirms LCM's utility as first add-on or conversion monotherapy in real-world settings.
Keywords:
Add-on therapyAntiseizure medicationsConversion monotherapyEpilepsyFocal seizuresReal-life studyMore Related Videos
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