Recent advances in regenerative medicine strategies for cancer treatment
Vahid Mansouri1, Nima Beheshtizadeh2, Maliheh Gharibshahian3
1Gene Therapy Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Regenerative Medicine group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Abstract:
Cancer stands as one of the most leading causes of death worldwide, while one of the most significant challenges in treating it is revealing novel alternatives to predict, diagnose, and eradicate tumor cell growth. Although various methods, such as surgery, chemotherapy, and radiation therapy, are used today to treat cancer, its mortality rate is still high due to the numerous shortcomings of each approach. Regenerative medicine field, including tissue engineering, cell therapy, gene therapy, participate in cancer treatment and development of cancer models to improve the understanding of cancer biology. The final intention is to convey fundamental and laboratory research to effective clinical treatments, from the bench to the bedside. Proper interpretation of research attempts helps to lessen the burden of treatment and illness for patients. The purpose of this review is to investigate the role of regenerative medicine in accelerating and improving cancer treatment. This study examines the capabilities of regenerative medicine in providing novel cancer treatments and the effectiveness of these treatments to clarify this path as much as possible and promote advanced future research in this field.
Insights
Regenerative medicine offers promising new strategies for cancer treatment, moving research from the lab to clinical application. This approach aims to improve prediction, diagnosis, and eradication of tumors, ultimately benefiting patients.
Area of Science:
- Oncology
- Regenerative Medicine
- Biomedical Engineering
Background:
- Cancer remains a leading global cause of death, with current treatments like surgery, chemotherapy, and radiation therapy having significant limitations.
- High cancer mortality rates persist despite existing therapeutic modalities, highlighting the urgent need for innovative treatment alternatives.
- Understanding cancer biology and developing effective treatment models are critical challenges in oncology.
Purpose of the Study:
- To investigate the role and potential of regenerative medicine in enhancing cancer treatment strategies.
- To explore novel regenerative medicine approaches for cancer prediction, diagnosis, and eradication.
- To bridge the gap between fundamental research and clinical application in cancer therapy, from bench to bedside.
Main Methods:
- Review of current literature on regenerative medicine applications in cancer.
- Analysis of tissue engineering, cell therapy, and gene therapy in cancer treatment and model development.
- Examination of the translation of laboratory findings to clinical cancer care.
Main Results:
- Regenerative medicine offers novel therapeutic avenues for cancer, including advanced treatment and diagnostic capabilities.
- Integration of regenerative medicine principles can improve the understanding of cancer biology and refine treatment efficacy.
- The field facilitates the development of improved cancer models for research and therapeutic testing.
Conclusions:
- Regenerative medicine holds significant potential to accelerate and improve cancer treatment outcomes.
- Further research and clinical translation are essential to fully realize the benefits of regenerative medicine in oncology.
- This field offers a promising pathway to reduce the burden of cancer on patients and healthcare systems.
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
01:30Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
01:19Mesenchymal Stem Cells
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...