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Raspberry Extract With Potential Antitumor Activity Against Cervical Cancer
Nelson Sham1, Chenglu Qin2,3, Ziwen Zhu3
1Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, IA, U.S.A.
Anticancer Research
|July 7, 2021
Summary
Raspberry extract (RE) shows anticancer effects against cervical cancer (CC) cells. RE up-regulates P53 and FAS, inhibiting cancer cell growth and promoting apoptosis.
Area of Science:
- Oncology
- Phytochemistry
- Molecular Biology
Background:
- Cervical cancer (CC) remains a significant global health concern.
- Previous research indicated blueberry extract inhibits CC growth.
- Raspberry extract (RE) has demonstrated antitumor properties, but its specific effect on CC is largely unstudied.
Purpose of the Study:
- To investigate the antitumor potential of RE on CC cells.
- To elucidate the molecular mechanisms underlying RE's effect on CC.
Main Methods:
- Utilized clonogenic survival assays and caspase-3 activity kits to assess RE's impact on HeLa cells.
- Employed reverse transcription-polymerase chain reaction (RT-PCR) to explore molecular mechanisms.
Main Results:
- RE significantly reduced HeLa cell survival and proliferation.
- Increased caspase-3 activity was observed in RE-treated cells, indicating apoptosis induction.
- RE treatment led to increased expression of the anti-proliferative P53 and pro-apoptotic FAS molecules.
Conclusions:
- Raspberry extract exhibits significant anticancer activity against cervical cancer cells.
- The mechanism involves the upregulation of P53 and FAS, leading to reduced proliferation and enhanced apoptosis.
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