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Radiotherapy as Elective Treatment of the Node-negative Neck in Oral Squamous Cell Cancer
Erik Lundin1,2, Johan Reizenstein2, Fredrik Landstrom3,4
1Institution for Medical Sciences, Örebro University, Örebro, Sweden; erik.lundin@regionorebrolan.se.
Background/Aim:
Previous studies of node-negative oral squamous cell carcinoma have shown a benefit of elective neck dissection compared to observation. Evidence for radiotherapy as single-modality elective treatment of the node-negative neck is so far lacking.
Patients And Methods:
In a retrospective material of 420 early-stage oral cancers from 2000 to 2016, overall survival, disease-free survival, and regional relapse-free survival were calculated with the Kaplan-Meier method.
Results:
At five years, overall survival was 59.7%, disease-specific survival was 77.2%, and regional relapse-free survival was 83.5%. Among those with adjuvant treatment of the neck after surgery of T1-T2 tumours during 2009-2016, regional relapse-free survival at five years was 85.7% for elective radiotherapy of the neck and 87.4% for elective neck dissection.
Conclusion:
Elective radiotherapy to the neck with a modern technique and adequate dose might be an alternative to neck dissection for patients with early-stage oral squamous cell cancer.
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