Anionic diketopiperazine induces osteogenic differentiation and supports osteogenesis in a 3D cryogel
Apurva Panjla1, Irfan Qayoom2, Ashok Kumar3
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, UP, India. sverma@iitk.ac.in.
Chemical Communications (Cambridge, England)
|July 7, 2021
Abstract:
Bioactive molecules that enhance or induce osteogenic potential of bone precursor cells have shown vital roles in bone tissue engineering. Herein, we report the design and synthesis of a novel diketopiperazine (DT) that induces osteoblastic differentiation of pre-osteoblasts and bone-marrow-derived stem cells in vitro and enhances the osteogenic potential of cryogel matrix. Such functional diketopiperazines can serve as potential scaffolds for bone healing and regeneration.
