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The Effect of Atorvastatin + Aspirin on the Endothelial Function Differs with Age in Patients with HIV: A

Gerson Gomes Dos Santos Junior1,2, Paulo Sérgio Ramos Araújo1,3, Kaliene Maria Estevão Leite1

  • 1Universidade Federal de Pernambuco - Pós-graduação em Medicina Tropical, Recife, PE - Brasil.

Arquivos Brasileiros De Cardiologia
|July 7, 2021
PubMed

Insights

Older individuals with HIV showed improved brachial artery flow-mediated dilation (FMD) after 6 months of atorvastatin and aspirin treatment. Cardiovascular risk factors were not significantly associated with reduced carotid intima-media thickness (IMT).

Area of Science:

  • Cardiovascular medicine
  • Infectious diseases
  • Pharmacology

Background:

  • Patients with HIV have a higher prevalence of cardiovascular disease compared to the general population.
  • Understanding factors influencing cardiovascular health in HIV patients is crucial for effective management.

Purpose of the Study:

  • To assess factors associated with reduced carotid intima-media thickness (IMT) and increased brachial artery flow-mediated dilation (FMD) in HIV patients.
  • To evaluate the impact of atorvastatin plus aspirin over 6 months on vascular markers in HIV-positive individuals.

Main Methods:

  • Secondary analysis of a clinical trial involving 38 HIV patients with low cardiovascular risk.
  • Carotid and brachial artery ultrasounds were performed before and after 6 months of treatment with atorvastatin + aspirin.
  • Patients were categorized into responders (improved IMT and FMD) and non-responders.

Main Results:

  • No significant association was found between reduced IMT and risk factors like age, gender, smoking, or time since HIV diagnosis.
  • Increased FMD was significantly associated with age in the 40-59 group (OR = 4.37, p = 0.015).

Conclusions:

  • Older individuals (40-59 years) were more likely to experience improved FMD.
  • Treatment with atorvastatin + aspirin may benefit vascular function in specific HIV patient subgroups.
Abstract

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