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Related Experiment Video

Updated: Oct 29, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

NEUROLOGICAL DYSFUNCTION ASSOCIATED WITH COVID-19.

Filipa Sofia Camacho Alves da Silva^1,2, Alexei Bucur², Steeve Neves Rosado²

¹Serviço de Medicina Interna, Centro Hospitalar de Setúbal - EPE - Setúbal, Portugal.

Revista Brasileira De Terapia Intensiva

|July 7, 2021

Summary

This summary is machine-generated.

This case study details a COVID-19 patient who developed severe neurological symptoms, including seizures and hemiparesis. SARS-CoV-2 was detected in the cerebrospinal fluid, indicating direct viral impact on the central nervous system.

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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

Area of Science:

Neurology
Infectious Diseases
Virology

Background:

The COVID-19 pandemic, caused by SARS-CoV-2, primarily presents with respiratory illness.
Neurological manifestations of SARS-CoV-2 infection are increasingly reported in scientific literature.
Understanding the neurological impact of SARS-CoV-2 is crucial for comprehensive patient management.

Observation:

A 45-year-old male patient with SARS-CoV-2 pneumonia developed acute neurological symptoms on day 16 of hospitalization.
Symptoms included altered consciousness, conjugate gaze deviation, myoclonus, generalized tonic-clonic seizures, and left hemiparesis.
The patient had no prior history of neurological disorders.

Findings:

Reverse transcription polymerase chain reaction (RT-PCR) confirmed the presence of SARS-CoV-2 in the cerebrospinal fluid (CSF).
This finding suggests direct central nervous system invasion by the virus.
The clinical presentation indicates a severe neurological complication directly linked to SARS-CoV-2 infection.

Implications:

This case highlights the potential for SARS-CoV-2 to cause significant neurological damage.
Detection of SARS-CoV-2 in CSF supports the hypothesis of neurotropism.
Further research is needed to elucidate the mechanisms of neuroinvasion and develop targeted therapies for COVID-19-associated neurological disorders.