Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Electric field-guided random-access DNA data storage.

Science advances·2026

Same author

Xeno nucleic acids (XNAs): advances in synthesis, diagnostics, and therapeutics.

Bioorganic chemistry·2026

Same author

Selective on-chip DNA synthesis using electric field-assisted PCR.

Lab on a chip·2026

Same author

Enhancing Community-Based Nursing Decision Support: Machine Learning Models for Diabetes Risk Prediction Using Home Health Nursing Notes.

Public health nursing (Boston, Mass.)·2026

Same author

Lifetime Atopic Dermatitis is Associated With Risk of Autoimmune Thyroid Disease: Evidence From a Nationwide Study.

Allergy, asthma & immunology research·2026

Same author

High-Data-Density, High-Decoding-Speed, and High-Decoding-Accuracy DNA Data Ink for Digital Preservation.

ACS nano·2026

Same journal

Engineered Young Brown Adipose Tissue-Derived Exosomes Alleviate Radiation-Induced Lung Injury by Promoting G Protein-Coupled Receptor 183 Ubiquitination.

ACS nano·2026

Same journal

Pore Geometry-Driven Capture of Trace Aromatic Volatile Organic Compounds in Al-Based MOFs.

ACS nano·2026

Same journal

Dual-Bridged Porphyrin-Based Covalent Organic Framework with Integrated Specific Fluorescent Recognition and Cooperative Adsorption Capabilities.

ACS nano·2026

Same journal

Split-Gate Memtransistors for Energy-Efficient Adaptive Reinforcement Learning.

ACS nano·2026

Same journal

Interface Coordination Nucleation of Copper Nanoclusters on Covalent Organic Frameworks for Electrocatalytic Ammonia Synthesis.

ACS nano·2026

Same journal

High-Performance Near-Infrared Quantum Emission from Color Centers in hBN.

ACS nano·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Oct 29, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

Programmable DNA-Based Boolean Logic Microfluidic Processing Unit.

Wonjin Lee¹, Minsang Yu¹, Doyeon Lim¹

¹Department of Nano-bioengineering, Incheon National University, Academy-to 119, Incheon, Korea, 22012.

|July 7, 2021

Summary

This summary is machine-generated.

This study introduces a programmable DNA-based microfluidic processing unit (MPU) for automated molecular computing. The DNA microfluidic chip enables complex Boolean logic operations, advancing DNA computing capabilities.

Keywords:

cascaded DNA biocomputing double-sided molding programmable DNA-based microfluidic processing unit servo motor valve spin coating three-dimensional printed microfluidic mold

More Related Videos

High-throughput Protein Expression Generator Using a Microfluidic Platform

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Related Experiment Videos

Last Updated: Oct 29, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

High-throughput Protein Expression Generator Using a Microfluidic Platform

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Area of Science:

Molecular computing
Biotechnology
Microfluidics

Background:

DNA strands enable molecular computing through chain reactions.
Current DNA logic computing often requires manual intervention.
Microfluidic chips offer automation and programmable control for DNA-based logic.

Purpose of the Study:

To present a programmable DNA-based microfluidic processing unit (MPU) chip.
To enable automated DNA calculations and Boolean logic operations.
To demonstrate the potential for complex circuit development using DNA computing.

Main Methods:

Fabrication of the DNA-based MPU using polydimethylsiloxane and double-sided molding.
Integration of servo motors for programmable valve switch control.
Implementation of cascaded DNA reactions for combinational logic operations (AND, OR).

Main Results:

Demonstration of basic AND and OR operations using input DNAs and a logic template DNA.
Successful execution of cascaded AND and OR operations.
Implementation of a 2-to-1 multiplexer and XOR operation using a three-step cascade reaction.

Conclusions:

The developed DNA-based MPU chip performs Boolean logic operations (AND, OR, NOT) with automated control.
The MPU can be programmed via a personal computer or smartphone application.
This technology is expected to facilitate the development of advanced functional circuits like ALUs and neuromorphic circuits.