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Small-molecule fluorescence-based probes for interrogating major organ diseases.
Hai-Hao Han1, He Tian, Yi Zang
1Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, China. xphe@ecust.edu.cn.
Small-molecule fluorescent probes enable real-time monitoring of organ function and disease biomarkers. This review highlights probe development for studying organ-related diseases in vitro and in vivo.
Area of Science:
- Biomedical Engineering
- Chemical Biology
- Molecular Imaging
Background:
- Real-time monitoring of organ function and cellular processes is crucial for biological research.
- Changes in specific biomarkers are linked to the development of organ-related diseases.
- Small-molecule fluorescent probes offer potential for advancing the understanding of these disorders.
Purpose of the Study:
- To review the development of small-molecule fluorescent probes for targeting organ-related processes.
- To highlight probe design strategies, optical responses to biomarkers, and biological applications.
- To discuss limitations, challenges, and opportunities in the field of fluorescent probe development.
Main Methods:
- Discussion of probe design strategies for targeting organ-related processes.
- Analysis of optical responses of probes to key biomarkers.
- Review of proof-of-concept biological studies for in vitro and in vivo applications.
Main Results:
- Development of various promising small-molecule fluorescent probes.
- Demonstration of probes' optical responses to key biomarkers.
- Validation of probe utility in proof-of-concept biological studies.
Conclusions:
- Small-molecule fluorescent probes are valuable tools for studying organ function and disease.
- Further development is needed to overcome limitations and address challenges in probe design and application.
- This review aims to inspire future research in developing fluorescent probes for organ-related diseases.
