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Published on: April 10, 2018
LMCD1 antisense RNA 1 is a newly identified long noncoding RNA
1Department of Medical Biology and Genetics, Institute of Health Sciences, Gaziantep University, Gaziantep, Turkey.
Abstract:
Long noncoding RNAs (lncRNAs) are one of the interesting fields in cancer researches. LncRNAs are generally dysregulated in many diseases. LMCD1 antisense RNA 1 (LMCD1-AS1) is a newly identified lncRNA with protumorigenic functions on tumor cells. LMCD1-AS1 expression is increased in hepatocellular carcinoma (HCC). LMCD1-AS1 is a sponge of miR-106b-5p activity. LMCD1-AS1 modulates the survival of osteosarcoma via targeting miR-106b-5p. LMCD1-AS1 and Sp1 are highly expressed in osteosarcoma. SP1 can bind to the promoter region of LMCD1-AS1, resulting in its overexpression in osteosarcoma. GLI2 is shown to bind to the LMCD1-AS1 promoter and is transcriptionally activated by LMCD1-AS1. LMCD1 acts as a miR-1287-5p sponge to increase GLI2 expression. LMCD1 is abundantly expressed in kidney tissue. Moreover, it is functionally involved in protein-protein interactions with transcriptional co-repressor activity, including regulation of the calcineurin-NFAT signaling cascade known to play a critical role in recovery from acute kidney injury (AKI). The E2F1/LMCD1-AS1/miR-345-5p/COL6A3 axis is a newly identified regulatory mechanism, which has a function in cholangiocarcinoma (CCA) tumorigenesis and progression and provides potential therapeutic targets for CCA. Also, LMCD1-AS1 functions in thyroid cancer (THCA) development. LMCD1-AS1 is overexpressed in THCA cells, and LMCD1-AS1 knockdown suppresses the malignant phenotypes of THCA cells. In THCA development, LMCD1-AS1 exerts protumorigenic function through sponging miR-1287-5p to increase GLI2 expression, constituting a feedback loop of LMCD1-AS1/miR-1287-5p/GLI2. In this review, the author focuses on the molecular mechanisms of newly identified long noncoding RNA LMCD1 antisense RNA 1 (LMCD1-AS1).
Insights
Long noncoding RNA LMCD1-AS1 promotes various cancers by interacting with microRNAs and transcription factors. This review details LMCD1-AS1
Area of Science:
- Molecular biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in disease.
- LMCD1 antisense RNA 1 (LMCD1-AS1) is a novel lncRNA implicated in cancer progression.
- Dysregulation of lncRNAs, including LMCD1-AS1, is observed across multiple cancer types.
Purpose of the Study:
- To review the molecular mechanisms of LMCD1-AS1 in cancer.
- To highlight LMCD1-AS1's role as a protumorigenic factor.
- To explore LMCD1-AS1's interactions with microRNAs and transcription factors.
Main Methods:
- Literature review of studies investigating LMCD1-AS1.
- Analysis of molecular pathways involving LMCD1-AS1.
- Examination of LMCD1-AS1 expression and function in various cancers.
Main Results:
- LMCD1-AS1 is overexpressed in hepatocellular carcinoma, osteosarcoma, cholangiocarcinoma, and thyroid cancer.
- LMCD1-AS1 acts as a molecular sponge for microRNAs (e.g., miR-106b-5p, miR-1287-5p, miR-345-5p).
- LMCD1-AS1 interacts with transcription factors like Sp1 and GLI2, influencing gene expression and promoting tumor growth.
Conclusions:
- LMCD1-AS1 plays a significant protumorigenic role in multiple cancers.
- LMCD1-AS1's interactions with miRNAs and transcription factors represent key regulatory mechanisms.
- LMCD1-AS1 is a potential therapeutic target for various malignancies.
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