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Updated: Oct 29, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Mendelian randomization analysis identified genes pleiotropically associated with central corneal thickness

Zhikun Yang1, Jingyun Yang2,3, Di Liu4

  • 1Department of Ophthalmology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing, China.

BMC Genomics
|July 8, 2021
PubMed
Summary

This study identified genes pleiotropically associated with central corneal thickness (CCT) in Europeans. Findings offer insights into CCT genetics and potential therapeutic targets for glaucoma and keratoconus.

Keywords:
Corneal thicknessExpression quantitative trait lociGenome-wide association studySummary Mendelian randomization

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