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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
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Long Non-coding RNA LINC01119 Promotes Neuropathic Pain by Stabilizing BDNF Transcript.
Le Zhang1, Hao Feng1, Yanwu Jin1
1Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Frontiers in Molecular Neuroscience
|July 8, 2021
Summary
Long non-coding RNA LINC01119 promotes neuropathic pain (NP) by stabilizing Brain-derived neurotrophic factor (BDNF) mRNA. Reducing LINC01119 alleviates NP symptoms and offers a potential diagnostic biomarker and therapeutic target for NP.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Neuropathic pain (NP) results from nervous system injury.
- Long non-coding RNAs (lncRNAs) are implicated in nervous system diseases, but their mechanisms in NP are unclear.
Purpose of the Study:
- To investigate the role of LINC01119 in neuropathic pain progression.
- To elucidate the post-transcriptional regulatory mechanism of LINC01119 in NP.
Main Methods:
- Utilized a rat model of spare nerve injury (SNI) to study NP.
- Investigated the interaction between LINC01119, ELAVL1, and BDNF mRNA using molecular biology techniques.
- Assessed serum LINC01119 levels in NP patients.
Main Results:
- LINC01119 was upregulated in the SNI rat model.
- Silencing LINC01119 reduced pain hypersensitivity and neuroinflammation (IL-6, IL-1β, TNF-α).
- LINC01119 binds to ELAVL1, stabilizing BDNF mRNA and increasing BDNF expression. Serum LINC01119 levels were elevated in NP patients.
Conclusions:
- LINC01119 promotes NP progression by enhancing BDNF mRNA stability and expression via the ELAVL1 complex.
- LINC01119 is a potential diagnostic biomarker and therapeutic target for neuropathic pain.
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