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Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity
L McEvoy1, D F Carr1, M Pirmohamed1
1Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom.
None:
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are widely used globally for the treatment of pain and inflammation, and in the case of aspirin, for secondary prevention of cardiovascular disease. Chronic non-steroidal anti-inflammatory drug use is associated with potentially serious upper gastrointestinal adverse drug reactions (ADRs) including peptic ulcer disease and gastrointestinal bleeding. A few clinical and genetic predisposing factors have been identified; however, genetic data are contradictory. Further research is needed to identify clinically relevant genetic and non-genetic markers predisposing to NSAID-induced peptic ulceration.
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