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Updated: Jun 20, 2026

Measuring Local Anaphylaxis in Mice
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Acetaminophen-induced anaphylaxis: a case report.

Jung Sunwoo1, Hyungsub Kim2, Kyun-Seop Bae1

  • 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Translational and Clinical Pharmacology
|July 8, 2021
PubMed
Summary
This summary is machine-generated.

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Anaphylaxis, a rare allergic reaction, can occur from acetaminophen, even without prior allergy history. This case highlights acetaminophen-induced anaphylaxis in a healthy individual during a clinical trial.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Allergy and Immunology

Background:

  • Acetaminophen is a widely used analgesic and antipyretic agent.
  • Anaphylaxis is a severe, potentially life-threatening allergic reaction.
  • Previous allergic reactions to acetaminophen are not always a prerequisite for anaphylaxis.

Observation:

  • A healthy male subject in a clinical trial experienced anaphylaxis.
  • The event occurred approximately 10 minutes after administration of 1300 mg oral acetaminophen.
  • The subject had received 150 mg ibandronate 12 hours prior to acetaminophen dosing.

Findings:

  • The patient developed generalized urticaria and hypotension, consistent with anaphylaxis.
  • The temporal relationship strongly suggested acetaminophen as the causative agent.
Keywords:
AcetaminophenAnaphylaxisDrug Hypersensitivity

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  • This case indicates that anaphylaxis to acetaminophen can manifest without prior sensitization.

    • Implications:

    • Healthcare providers should be aware of the potential for rare acetaminophen-induced anaphylaxis.
    • Further investigation into the mechanisms of acetaminophen hypersensitivity may be warranted.
    • Patients should be monitored for allergic reactions following acetaminophen administration, even if previously tolerated.