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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report
Miguel Mayo-Yáñez1,2, Andrea Díaz-Díaz3, Juan C Vázquez-Barro1,4
1Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Complex of A Coruña (CHUAC), A Coruña, Galicia.
Allergologie Select
|July 8, 2021
Summary
Reduced diamine oxidase (DAO) activity, crucial for histamine breakdown, correlates with lower nasal airflow in persistent allergic rhinitis patients. This suggests DAO may play a role in the condition
Area of Science:
- Immunology
- Biochemistry
Background:
- Histamine is a key mediator in allergic rhinitis.
- Diamine oxidase (DAO) is the primary enzyme responsible for histamine catabolism.
Purpose of the Study:
- To investigate the relationship between diamine oxidase (DAO) activity and symptoms in persistent allergic rhinitis.
- To determine if DAO activity levels can serve as a biomarker for allergic rhinitis severity.
Main Methods:
- A descriptive and analytical observational study was conducted.
- DAO activity levels and nasal peak inspiratory flow were measured in 108 patients.
Main Results:
- A deficit in DAO enzymatic activity was observed in 46.3% of patients.
- Patients with DAO activity deficit showed significantly lower nasal peak inspiratory flow (76.30 L/min) compared to those with normal activity (93.62 L/min).
- No significant difference in DAO activity was found between mild and moderate/severe rhinitis groups (p = 0.376).
Conclusions:
- Lower DAO catabolic activity appears to be associated with reduced nasal peak inspiratory flow.
- While DAO activity might indicate allergic rhinitis severity, a direct causal link is not established.
- DAO may be implicated in the pathophysiology of allergic rhinitis.
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