Antimicrobial Susceptibility Testing for Mycobacterium sps in High-Throughput Format.

Area of Science:

• Clinical microbiology
• Pharmacology
• Drug discovery

Background:

• Antimicrobial susceptibility testing (AST) is fundamental in clinical microbiology.
• AST aids in identifying novel antibiotics and determining their therapeutic applications.

Purpose of the Study:

• To present diverse methodologies for evaluating compound activity.
• To focus on approaches suitable for medium or high-throughput screening.

Main Methods:

• Description of various antimicrobial susceptibility testing techniques.
• Adaptation of methods for scalability in screening.

Main Results:

• Outlined approaches for assessing compound efficacy.
• Demonstrated applicability in different throughput settings.

Conclusions:

• The described methods facilitate efficient evaluation of antimicrobial compounds.
• These approaches support the antibiotic discovery pipeline.