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Regional gray matter volume associated with exercise dependence: A voxel-based morphometry study.

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This summary is machine-generated.

Excessive exercise can lead to exercise dependence (EXD). This study found that reduced gray matter volume in specific brain regions mediates the link between stress and EXD, offering insights into its neurobiological underpinnings.

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Area of Science:

  • Neuroscience
  • Psychology
  • Radiology

Background:

  • Regular physical activity offers benefits, but excessive exercise can result in exercise dependence (EXD).
  • Stress is increasingly recognized as a risk factor for developing EXD.
  • The neural mechanisms linking stress and EXD remain largely unexplored.

Purpose of the Study:

  • To investigate the neuroanatomical correlates of exercise dependence (EXD).
  • To explore the neuropsychological mechanisms through which stress influences EXD.
  • To identify brain regions associated with the relationship between stress and EXD.

Main Methods:

  • Structural magnetic resonance imaging (sMRI) was used to estimate cortical gray matter volume (GMV).
  • Voxel-based morphometry (VBM) was applied to analyze GMV differences in 86 regular exercisers.
  • Whole-brain correlation, prediction, and mediation analyses were conducted to examine relationships between EXD, stress, and GMV.

Main Results:

  • Negative correlations were observed between EXD and GMV in the right orbitofrontal cortex (OFC), left subgenual cingulate gyrus (sgCG), and left inferior parietal lobe (IPL).
  • GMV of the right OFC significantly mediated the relationship between stress and EXD.
  • These findings were robust, persisting after controlling for demographic, socioeconomic, and psychological variables.

Conclusions:

  • The study provides neuroanatomical evidence for the neural basis of EXD.
  • A neuropsychological pathway is identified where GMV mediates the impact of stress on EXD.
  • These findings contribute to understanding the neurobiology of exercise dependence and stress.