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Neural Control of Respiration01:18

Neural Control of Respiration

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The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
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Related Experiment Video

Updated: Oct 29, 2025

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
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Real-Time Respiratory Tumor Motion Prediction Based on a Temporal Convolutional Neural Network: Prediction Model

Panchun Chang1,2, Jun Dang1, Jianrong Dai3

  • 1Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Journal of Medical Internet Research
|July 8, 2021
PubMed
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A deep learning model using temporal convolutional neural networks accurately predicts tumor locations for radiation therapy. This advance minimizes time latency in dynamic tumor tracking, improving treatment precision.

Keywords:
deep learning modeldynamic trackingneural networkradiation therapyrespiratory signal predictiontemporal convolutional neural network

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Area of Science:

  • Medical Physics
  • Artificial Intelligence in Medicine
  • Radiation Oncology

Background:

  • Dynamic tumor tracking in radiation therapy necessitates real-time target location prediction.
  • Time latency in radiation beam delivery and gating tracking poses a challenge.

Purpose of the Study:

  • To develop a deep learning model for predicting internal tumor locations using external markers.
  • To improve real-time target tracking in radiation therapy by overcoming time latency.

Main Methods:

  • A temporal convolutional neural network (TCNN) model was developed to predict internal target locations.
  • The model was trained and tested using respiratory signals from 69 treatment fractions of 21 cancer patients treated with CyberKnife Synchrony.
  • Performance was evaluated by comparing root mean square errors (RMSEs) against a long short-term memory (LSTM) model and investigating the impact of external marker count.

Main Results:

  • The TCNN model achieved average RMSEs of 0.49 mm (superior-inferior), 0.28 mm (anterior-posterior), 0.25 mm (left-right), and 0.67 mm (3D) for predicted respiratory motion 400 ms ahead.
  • Submillimeter accuracy was demonstrated in predicting respiratory signals.

Conclusions:

  • The developed temporal convolutional neural network-based model can predict respiratory signals with submillimeter accuracy.
  • This predictive capability is crucial for enhancing real-time tumor tracking and reducing latency in radiation therapy.