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Related Concept Videos

Tracheostomy Decannulation01:21

Tracheostomy Decannulation

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Tracheostomy decannulation is a significant milestone in the liberation of mechanically ventilated patients. Despite its importance, there is no universally accepted protocol for this procedure. This demands an evidence-based, individualized approach.
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
519

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Related Experiment Video

Updated: Oct 29, 2025

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
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Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model

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Single-stage long-segment tracheal transplantation.

Eric M Genden1,2, Brett A Miles1, Timothy J Harkin3,4

  • 1Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|July 8, 2021
PubMed
Summary
This summary is machine-generated.

This study reports the first single-stage tracheal transplantation in humans for long-segment defects. Six months post-surgery, the transplanted trachea is functional, allowing the patient to breathe unaided.

Keywords:
clinical research/practiceorgan procurementsurgical techniquevascularized composite and reconstructive transplantation

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Area of Science:

  • Regenerative Medicine
  • Transplantation Surgery
  • Pulmonary Medicine

Background:

  • Long-segment tracheal defects pose significant reconstruction challenges.
  • Current treatments often involve complex procedures with limited success.
  • Tracheal transplantation offers a potential solution for severe airway reconstruction.

Purpose of the Study:

  • To report the first human single-stage tracheal transplantation.
  • To evaluate the feasibility and outcomes of allogeneic tracheal grafts.
  • To assess graft viability and airway function post-transplantation.

Main Methods:

  • Performed a single-stage tracheal transplantation for a long-segment defect.
  • Utilized narrow-band imaging and bronchoscopic biopsies for assessment.
  • Administered immunosuppression with Tacrolimus, Mycophenolate mofetil, and corticosteroids.

Main Results:

  • Demonstrated successful allograft vascularization and epithelial lining viability via imaging and biopsies.
  • The patient achieved unaided breathing six months after transplantation.
  • The transplanted trachea was confirmed to be functional without the need for a tracheostomy or stent.

Conclusions:

  • Single-stage tracheal transplantation is a viable option for long-segment tracheal defects.
  • Successful allograft integration and function were achieved in this first human case.
  • This approach holds promise for improving outcomes in tracheal reconstruction.