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Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
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Aortic Root Replacement for Destructive Endocarditis - Clinic and Microbiology.
Marcin P Szczechowicz1, Alexander Weymann1, Sabreen Mkalaluh2
1Department of Cardiac Surgery, University of Duisburg-Essen, Essen, Germany.
Brazilian Journal of Cardiovascular Surgery
|July 8, 2021
Summary
Destructive aortic root endocarditis, particularly prosthetic valve endocarditis (PVE), presents a high mortality risk. Early diagnosis and appropriate treatment are crucial for improving outcomes in these complex cases.
Area of Science:
- Cardiovascular Surgery
- Infectious Diseases
- Medical Microbiology
Background:
- Destructive aortic root endocarditis carries significant mortality.
- Prosthetic valve endocarditis (PVE) poses unique challenges compared to native valve endocarditis (NVE).
Purpose of the Study:
- To characterize clinical and microbiological profiles of patients with destructive aortic root endocarditis.
- To identify prognostic factors for mortality, especially in cases involving prosthetic aortic valves.
Main Methods:
- Retrospective analysis of 80 patients undergoing aortic root replacement for destructive endocarditis (1999-2018).
- Evaluation of pre-, intra-, and postoperative data, outcomes, and mortality predictors.
- Categorization into native valve endocarditis (NVE), early-onset PVE, and late-onset PVE groups.
Main Results:
- Coagulase-negative Staphylococcus was the primary pathogen in early-onset PVE.
- Aortoventricular dehiscence, PVE, bypass surgery, and delayed diagnosis were independent mortality risk factors.
- Late-onset PVE patients demonstrated better long-term survival and freedom from composite endpoints compared to NVE patients.
Conclusions:
- Delayed diagnosis and inadequate treatment exacerbate destructive endocarditis complications and prognosis.
- Prosthetic valve endocarditis is associated with higher mortality rates than native valve endocarditis.
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