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RhoA/ROCK-1 Signaling Pathway and Oxidative Stress in Coronary Artery Disease Patients

Eda Dokumacioglu1, Ibrahim Duzcan2, Hatice Iskender1

  • 1Department of Nutrition and Dietetics, Faculty of Healthy Sciences, Artvin Çoruh University, Artvin, Turkey.

Brazilian Journal of Cardiovascular Surgery
|July 8, 2021
PubMed

Insights

This study found elevated RhoA/Rho-associated kinase (ROCK)-1 signaling and oxidative stress markers in coronary artery disease (CAD) patients. Inhibiting this pathway may benefit cardiovascular disease treatment.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biochemistry

Background:

  • Coronary artery disease (CAD) is an ischemic condition caused by narrowed or blocked coronary arteries, impairing blood flow to the heart.
  • The RhoA/Rho-associated kinase (ROCK)-1 signaling pathway and oxidative stress are implicated in cardiovascular pathophysiology.

Purpose of the Study:

  • To investigate the role of the RhoA/ROCK-1 signaling pathway in CAD.
  • To assess oxidative stress markers in patients with CAD.

Main Methods:

  • Serum samples from 45 CAD patients and 36 healthy controls (aged 40-70) were analyzed.
  • Measurements included lipid profiles, malondialdehyde (MDA), superoxide dismutase (SOD), RhoA, and ROCK-1 levels.

Main Results:

  • CAD patients exhibited significantly higher serum levels of RhoA, MDA, and ROCK-1 activity compared to controls (P<0.001).
  • Serum SOD activity was significantly lower in the CAD group than in the control group (P<0.001).

Conclusions:

  • The RhoA/ROCK-1 pathway is upregulated in CAD patients.
  • Increased oxidative stress, indicated by MDA and SOD levels, is associated with CAD.
  • Inhibiting the RhoA/ROCK-1 pathway may offer a therapeutic strategy for cardiovascular diseases.
Abstract

Keywords:
Coronary Artery DiseaseMalondialdehydeOxidative StressRHOA protein, humanRho-Associated KinasesSignal TransductionSuperoxide Dismutase

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