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Related Experiment Video

Updated: Oct 29, 2025

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Orthostatic intolerance in post-concussion patients.

Sara J Gould^1,2, Graham D Cochrane³, Jarvis Johnson⁴

¹Department of Orthopedic Surgery, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.

The Physician and Sportsmedicine

|July 8, 2021

Summary

Pediatric concussion can cause orthostatic intolerance (OI), affecting 8.7% of patients. Recovery takes a median of 120 days, differing from other OI causes.

Keywords:

Concussion fludrocortisone orthostatic intolerance postural orthostatic tachycardia syndrome tilt table test

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Published on: September 21, 2018

Area of Science:

Neurology
Pediatrics
Sports Medicine

Background:

Orthostatic intolerance (OI) following pediatric concussion is not well understood.
Assessing concussion-related OI prevalence and characteristics is crucial for improving patient care.
Previous research has not sufficiently detailed the differences between concussion-related and non-concussion-related OI.

Purpose of the Study:

To describe concussion-related OI in adolescents.
To determine the time to recovery for concussion-related OI.
To compare concussion-related OI with general OI statistics, including sex-based prevalence.

Main Methods:

Retrospective chart review of pediatric patients with post-concussion OI symptoms.
Analysis of patient sex, sport history, previous concussions, time since injury, and recovery time.
Comparison of data between males and females and against general OI statistics.

Main Results:

39 pediatric patients (8.7% of new clinic referrals) were included.
Median recovery time was 120 days.
94% of tested patients showed an orthostatic tachycardic response; concussion-related OI lacks strong female predominance and has a shorter recovery than other OI types.

Conclusions:

Concussion-related OI presents differently from other OI etiologies, notably in sex distribution and recovery duration.
Clinical orthostatic vital signs may be less sensitive in diagnosing OI in athletes.
Further research is needed to understand the unique pathophysiology and management of post-concussive OI.