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Updated: Oct 29, 2025

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NDNF interneurons, Spartans of the cortical column: Small in number, strong in impact
Hyeyoung Shin1, Hillel Adesnik2
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Neuron
|July 8, 2021
Abstract:
NDNF selectively labels neurogliaform inhibitory interneurons of layer 1. In this issue of Neuron, Cohen-Kashi Malina et al. (2021) show that NDNF activity is highly correlated with arousal level. During high arousal state, NDNF inhibits the dendrites while disinhibiting the soma of nearby pyramidal neurons.
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