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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Sandwich-like Microenvironments to Harness Cell/Material Interactions
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2D biointerfaces to study stem cell-ligand interactions.

Xingzhen Zhang1, Sabine van Rijt1

  • 1Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, MD Maastricht 6200, the Netherlands.

Acta Biomaterialia
|July 8, 2021
PubMed
Summary
This summary is machine-generated.

Biointerfaces are engineered surfaces that control stem cell adhesion and behavior. This review explores how these cell-instructive materials guide stem cell regeneration for tissue engineering and medicine.

Keywords:
BiointerfacesCell–material interactionDynamic biointerfacesRegenerative medicineStem cells

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Stem cells hold significant promise for tissue engineering and regenerative medicine.
  • Clinical translation of stem cells is hindered by challenges in controlling transplanted cell behavior.
  • Stem cell behavior is dictated by interactions with their microenvironment, known as stem cell niches.

Purpose of the Study:

  • To review recent advancements in fabricating cell-instructive biointerfaces.
  • To explore how these interfaces control cell adhesion processes.
  • To direct stem cell behavior for therapeutic applications.

Main Methods:

  • Discussion of static surfaces with predefined biochemical signals to study chemical feature effects.
  • Analysis of dynamic platforms with spatiotemporal control of biochemical cues (on-off ligand display, reversible ligand display, ligand mobility).
  • Review of biointerface fabrication techniques for controlling cell adhesion.

Main Results:

  • Static surfaces can probe the impact of chemical signals on stem cell behavior.
  • Dynamic platforms offer spatiotemporal control over biochemical cues, enabling more sophisticated manipulation of stem cell interactions.
  • Biointerfaces are effective tools for studying stem cell-niche interactions.

Conclusions:

  • Cell-instructive biointerfaces are crucial for understanding and controlling stem cell behavior.
  • Advancements in biointerface design are paving the way for improved stem cell-based therapies.
  • Future biointerface designs hold potential for enhanced regenerative medicine strategies.