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[Morphology of the sick sinus node].

R Candinas1, J Schneider

  • 1Institut für Pathologie der Universität Zürich.

Schweizerische Medizinische Wochenschrift
|October 24, 1987
PubMed
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Sick sinus syndrome (SSS) involves increased collagen in the sino-atrial node, though node size remains similar to healthy hearts. The sino-atrial node and conduction system often degenerate concurrently in SSS patients.

Area of Science:

  • Cardiology
  • Pathology
  • Electrophysiology

Background:

  • Sick sinus syndrome (SSS) is a common cause of cardiac arrhythmias.
  • The underlying pathology of SSS is not fully understood.
  • Previous studies have suggested structural changes in the sino-atrial node.

Purpose of the Study:

  • To quantitatively compare the structural characteristics of sino-atrial nodes from patients with SSS and healthy individuals.
  • To investigate potential correlations between SSS and the health of the cardiac conduction system.

Main Methods:

  • A comparative study of 65 autopsy hearts.
  • Quantitative analysis of 40-50 serial sections per sino-atrial node using light microscopy.
  • Assessment of collagen content and node size.

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Main Results:

  • Sino-atrial nodes in SSS patients and healthy controls were of comparable size.
  • A significantly higher content of collagenous fibers was observed in the sino-atrial nodes of SSS patients.
  • A tendency for concurrent degeneration of the sino-atrial node and the cardiac conduction system was noted in SSS cases.

Conclusions:

  • Increased collagen deposition is a key structural feature of the sino-atrial node in SSS.
  • SSS may involve a simultaneous pathological process affecting both the sino-atrial node and the broader conduction system.
  • Ischemia is unlikely to be the primary cause of SSS in most cases studied.