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Updated: Oct 29, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

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Acute respiratory distress syndrome in paediatric scrub typhus

Sathish K Loganathan1, Amol Jaybhaye2, Nabaneeta Dash3

  • 1Assistant Professor, Department of Paediatrics, CMC, Vellore, India.

Tropical Doctor
|July 9, 2021
PubMed

Insights

Acute respiratory distress syndrome (ARDS) is a severe complication of scrub typhus. This study identified key factors like eschar, enlarged liver, and low platelets associated with ARDS mortality in Indian children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Scrub typhus is a significant cause of febrile illness in many parts of the world.
  • Acute respiratory distress syndrome (ARDS) is a life-threatening complication of scrub typhus, particularly in pediatric cases.
  • Understanding ARDS-associated mortality factors in scrub typhus is crucial for improving patient outcomes.

Purpose of the Study:

  • To describe the mortality rate of acute respiratory distress syndrome (ARDS) in children with scrub typhus.
  • To identify clinical and laboratory factors associated with ARDS mortality in this population.

Main Methods:

  • A retrospective study was conducted involving 65 children diagnosed with scrub typhus.
  • Data collected included the presence of eschar, hepatomegaly, severe thrombocytopenia, and outcomes related to ARDS.

Main Results:

  • The study identified specific factors associated with increased mortality in pediatric scrub typhus patients who developed ARDS.
  • Eschar, hepatomegaly, and severe thrombocytopenia were noted as significant indicators.

Conclusions:

  • Acute respiratory distress syndrome (ARDS) presents a high mortality risk in pediatric scrub typhus.
  • Prompt recognition and management of associated factors such as eschar, hepatomegaly, and severe thrombocytopenia are vital for improving survival rates in children with scrub typhus-induced ARDS.

Keywords:
IndiaScrub typhusacute respiratory distress syndromepaediatrics

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