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Modified Octopus Technique for Thoracoabdominal Aortic Aneurysm
Published on: August 1, 2025
253
Primary angiosarcoma of aorta: A systematic review.
Ali Kordzadeh1, Alan Askari2, Ali Navi2
1Mid & South Essex Foundation Trust, Broomfield Hospital, Chelmsford, UK.
Vascular
|July 9, 2021
Summary
Primary angiosarcoma of the aorta is rare, often presenting in the abdomen. Survival is significantly impacted by metastasis, with earlier diagnosis improving outcomes.
Area of Science:
- Vascular Surgery
- Oncology
- Pathology
Background:
- Primary angiosarcoma of the aorta is an exceptionally rare and aggressive malignancy.
- Understanding its epidemiology and clinical characteristics is crucial for improved patient outcomes.
Purpose of the Study:
- To comprehensively review the epidemiology, anatomical distribution, clinical presentation, classification, pathology, diagnostic modalities, management strategies, and prognosis of primary angiosarcoma of the aorta.
Main Methods:
- A systematic literature review was conducted across major databases (PubMed, Embase, CINAHL, Cochrane Library) following PRISMA guidelines.
- Data extraction and quality assessment were performed by two independent reviewers.
- Pooled prevalence, survival analysis (Kaplan-Meier), and log-rank tests were utilized for data analysis.
Main Results:
- A total of 123 cases from 82 studies were included. The abdominal aorta was the most common site (45%).
- Female predominance was noted in ascending aorta (4:1) and aortic arch (2:1) cases.
- Median survival was 210 days (7 months). Absence of metastasis was a significant predictor of longer survival (p < 0.03).
Conclusions:
- Primary angiosarcoma of the aorta exhibits a trend towards increasing systemic symptoms and segmental aortic dysfunction.
- Characteristic CT angiography findings include bulky, hypervascular, intraluminal masses without atherosclerotic changes, often seen in the 5th and 6th decades.
- Early detection and absence of metastasis are critical for improving the poor prognosis associated with this rare tumor.
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