Related Experiment Video
Updated: Oct 29, 2025
06:34
Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices
Published on: November 29, 2024
421
Formulation Development and In-vitro/Ex-vivo Evaluation for a Polysaccharide-based Colon Targeted Matrix Tablet
Mohsina Shaikh1, Neha Desai2, Munira Momin2
1Department of Quality Assurance, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai,India.
Current Drug Delivery
|July 9, 2021
Summary
This study developed a microflora-triggered colon-targeted drug delivery system using Gum Ghatti (GG) and Hydroxypropyl Methylcellulose (HPMC K100). The optimized formulation demonstrated stability and effective drug release, showing promise for sustained drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Colon targeted drug delivery aims to improve therapeutic efficacy by releasing drugs directly in the colon.
- Natural polymers like Gum Ghatti (GG) offer potential for developing novel drug delivery systems due to their biocompatibility and biodegradability.
- Hydrophilic polymers such as Hydroxypropyl Methylcellulose (HPMC K100) are widely used in sustained-release formulations.
Purpose of the Study:
- To develop and optimize a microflora-triggered, colon-targeted, sustained-release dosage form.
- To utilize Gum Ghatti (GG) and Hydroxypropyl Methylcellulose (HPMC K100) as key components for the dosage form.
- To establish a platform technology for various drug categories using this formulation approach.
Main Methods:
- Tablets containing metoprolol succinate and mesalamine were prepared using GG and HPMC K100.
- Tablets were enteric-coated with Eudragit® L100 and Eudragit® S100.
- Formulations were evaluated for physical properties, drug content, and in vitro/ex vivo drug release, including microflora-induced release using rat cecal content.
Main Results:
- In vitro drug release showed 86.03% metoprolol succinate and 80.26% mesalamine release over 12 hours.
- Ex vivo studies with rat cecal content demonstrated higher release: 96.50% metoprolol succinate and 92.58% mesalamine within 12 hours.
- The developed formulation exhibited good stability under standard ICH conditions.
Conclusions:
- Gum Ghatti (GG) and Hydroxypropyl Methylcellulose (HPMC K100) are suitable for creating microflora-triggered, colon-targeted matrix tablets.
- The developed dosage form shows potential for effective and sustained drug delivery to the colon.
- This platform technology can be adapted for various therapeutic agents requiring colon targeting.
Related Concept Videos
01:18Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
35
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
35
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
33
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
33
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
235
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
235
01:16Methods for Studying Drug Absorption: In vitro
414
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
414
01:27Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
36
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
36
01:27Bioavailability Enhancement: Drug Permeability Enhancement
41
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
41