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Contrast-induced Nephropathy in Non-cardiac Vascular Procedures, A Narrative Review: Part 1
Juliette Raffort1, Fabien Lareyre2, Niki Katsiki3
1Clinical Chemistry Laboratory, University Hospital of Nice, France | Université Côte d'Azur, CHU, Inserm U1065, C3M, Nice, France.
Insights
Contrast-induced Nephropathy (CIN) is a risk after iodinated Contrast Medium (CM) use in non-cardiac vascular procedures. Awareness and preventive strategies are crucial for managing this complication and improving patient outcomes.
Area of Science:
- Nephrology
- Vascular Surgery
- Radiology
Background:
- Contrast-induced Nephropathy (CIN) is a significant complication following iodinated Contrast Medium (CM) administration.
- While often studied in cardiac procedures, CIN also occurs after non-cardiac vascular interventions.
Purpose of the Study:
- To review the literature on CIN following non-cardiac vascular procedures for aortic aneurysm and carotid stenosis.
- To discuss CIN's definition, pathophysiology, incidence, risk factors, biomarkers, consequences, and prevention.
Main Methods:
- Narrative review of existing literature.
- Focus on diagnostic or therapeutic non-cardiac vascular procedures.
Main Results:
- CIN is associated with adverse short- and long-term outcomes, including cardiorenal events, extended hospitalization, and mortality.
- Identified risk factors, biomarkers, and consequences of CIN in specific non-cardiac vascular settings.
Conclusions:
- Physicians and vascular surgeons must recognize CM-related risks and employ preventive strategies.
- Further research is essential to better understand and mitigate CIN in these patient populations.
Abstract:
Contrast-induced Nephropathy (CIN) is animportant complication of iodinated Contrast Medium (CM) administration, being associated with both short- and long-term adverse outcomes (e.g., cardiorenal events, longer hospital stay and mortality). CIN has been mainly studied in relation to cardiac procedures but it can also occur following non-cardiac vascular interventions. This is Part 1 of a narrative review summarizing the available literature on CIN after non-cardiac vascular diagnostic or therapeutic procedures for aortic aneurysm and carotid stenosis. We discuss the definition, pathophysiology, incidence, risk factors, biomarkers and consequences of CIN in these settings, as well as preventive strategies and alternatives to limit iodinated CM use. Physicians and vascular surgeons should be aware of CM-related adverse events and the potential strategies to avoid it. Clearly, more research in this important field is required.
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