Related Experiment Video

Updated: Oct 29, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.5K

Predictors of mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis

Changcheng Shi1, Limin Wang2, Jian Ye2

  • 1Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

BMC Infectious Diseases
|July 9, 2021
PubMed

Insights

Identifying COVID-19 mortality predictors is crucial for patient outcomes. Advanced age, male sex, comorbidities, dyspnea, and abnormal lab results are key risk factors for fatal outcomes in coronavirus disease 2019.

Area of Science:

  • Epidemiology
  • Clinical Medicine
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) presents a significant mortality risk, particularly in severe cases.
  • Understanding predictors of mortality is essential for effective clinical management.

Purpose of the Study:

  • To systematically review and meta-analyze potential predictors of mortality in patients diagnosed with COVID-19.

Main Methods:

  • Searched multiple databases (PubMed, EMBASE, Cochrane, Chinese databases) from December 2019 to April 2020.
  • Included 36 observational studies, with 27 selected for meta-analysis.
  • Pooled unadjusted prognostic estimates using random-effects models and analyzed adjusted estimates qualitatively.

Main Results:

  • Identified 106 potential risk factors, confirming advanced age, male sex, smoking, and comorbidities (kidney, respiratory, cardiovascular) as significant predictors.
  • Dyspnea, hospitalization complications, corticosteroid use, and severe condition were associated with increased mortality.
  • Abnormalities in hematologic, hepatorenal, inflammatory, coagulation, and cardiovascular biomarkers also correlated with fatal outcomes.

Conclusions:

  • Key predictors of COVID-19 mortality have been identified.
  • Findings can guide healthcare providers in implementing targeted interventions to improve patient outcomes.
Abstract

Keywords:
COVID-19Meta-analysisMortalityPredictorsSystematic review

More Related Videos

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

14.8K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.9K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
78
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
553
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.1K
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.7K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
539