Related Experiment Video
Updated: Oct 29, 2025

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
Published on: October 13, 2023
Eagle syndrome: toward a clinical delimitation.
N González-García1, J Porta-Etessam1, D García-Azorín2
1Hospital Clínico San Carlos, Madrid, Spain.
Eagle syndrome (ES) is a rare cause of craniofacial pain, often misdiagnosed. Neuromodulatory therapy effectively treated four of five patients presenting with symptoms of this condition.
Area of Science:
- Neurology
- Otolaryngology
- Pain Medicine
Background:
- Orofacial and cervical pain are common neurological complaints.
- Eagle syndrome (ES) is a rare condition linked to stylohyoid ligament calcification or styloid process elongation.
- This study presents five new cases of ES.
Purpose of the Study:
- To describe the clinical characteristics of Eagle syndrome.
- To report on the treatment responses in patients with ES.
- To highlight ES as a potentially underdiagnosed cause of craniofacial pain.
Main Methods:
- Retrospective case series of 5 patients with symptoms suggestive of Eagle syndrome.
- Demographic and clinical data were collected.
- Treatment outcomes were analyzed, including imaging (CT scans) and therapeutic responses.
Main Results:
- Patients (3 male, 2 female; ages 24-51) presented with dull, intense pain in the ear and tonsillar fossa, exacerbated by swallowing.
- CT scans confirmed styloid process elongation or ligament calcification in 3 patients.
- Four patients responded well to neuromodulatory drugs; one required surgery.
Conclusions:
- Eagle syndrome is a rare, potentially underdiagnosed cause of craniofacial pain.
- The presented cases illustrate typical symptoms and treatment outcomes for ES.
- Neuromodulatory therapy offers a viable treatment option for Eagle syndrome.
More Related Videos
Related Concept Videos
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome III: Diagnostic Studies

