Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.4K
Bone Remodeling01:40

Bone Remodeling

39.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.0K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.4K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.4K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.2K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

5.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.0K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

2.6K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of Complement Component 9 in Bone Health: Causal Evidence in Humans and Mechanistic Studies in Mice.

Calcified tissue international·2026
Same author

Glyphosate exposure, bone mineral density, osteoporosis, and fractures in the United States population.

Journal of environmental health science & engineering·2026
Same author

Treatment with the Bifidobacterium longum Strain DSM 32947 Increases Bone Mineral Density in Female Mice.

Calcified tissue international·2025
Same author

Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice.

Bone research·2025
Same author

The beneficial effects of a probiotic mix on bone and lean mass are dependent on the diet in female mice.

Scientific reports·2025
Same author

An atlas of genetic determinants of forearm fracture.

Nature genetics·2023
Same journal

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026
Same journal

International expert Delphi consensus on thromboprophylaxis in metabolic and bariatric surgery.

Scientific reports·2026
Same journal

Assessing the cross-region knowledge transfer capability of selected deep learning building vectorization methods in the context of available training datasets.

Scientific reports·2026
Same journal

Feasibility and preliminary effects of outdoor versus indoor cognitive-motor therapy in women with Alzheimer's disease: A randomized single-blind pilot study.

Scientific reports·2026
Same journal

Hallmarks of social action in the vocal turn-taking of wild common marmosets (Callithrix jacchus).

Scientific reports·2026
Same journal

Role and mechanism of AOPPs-induced NOX4-mediated ferroptosis in intervertebral disc degeneration.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Oct 29, 2025

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

724

Acute fat loss does not affect bone mass.

Marie K Lagerquist1, Karin L Gustafsson1, Petra Henning1

  • 1Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Su Sahlgrenska, Vita Stråket 11, 413 45, Gothenburg, Sweden.

Scientific Reports
|July 9, 2021
PubMed
Summary
This summary is machine-generated.

Acute loss of adipose tissue did not affect bone mass or strength in obese mice, even with reduced mechanical loading. Further research is needed for more severe obesity cases.

More Related Videos

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.8K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

664

Related Experiment Videos

Last Updated: Oct 29, 2025

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

724
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.8K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

664

Area of Science:

  • Bone biology
  • Adipose tissue biology
  • Obesity research

Background:

  • High body weight and BMI are traditionally linked to high bone mass, suggesting a protective role for obesity.
  • Recent studies indicate that increased adiposity may negatively impact bone mass, challenging previous assumptions.
  • The relationship between adipose tissue and bone health in obesity requires further investigation.

Purpose of the Study:

  • To investigate the effect of acute adipose tissue loss on bone mass in age-related obese mice.
  • To determine if adipocyte apoptosis influences bone mass and biomechanical properties.
  • To assess the impact of reduced mechanical loading due to fat loss on bone.

Main Methods:

  • Obese male FAT-ATTAC mice were used to induce adipocyte apoptosis via AP20187 dimerizer-mediated activation of caspase 8.
  • Two experiments were conducted: a short-term (2 weeks) and a long-term (6 weeks) study.
  • Bone mass and biomechanical properties were assessed after adipose tissue reduction.

Main Results:

  • In the short-term study, a 58% reduction in fat mass did not alter bone mass.
  • In the long-term study, a 68% reduction in fat mass did not affect bone mass or biomechanical properties.
  • Adipose tissue loss did not negatively impact bone, despite decreased mechanical loading.

Conclusions:

  • Acute loss of adipose tissue does not alter bone mass or biomechanical properties in age-related obese mice.
  • The findings suggest that reduced mechanical loading from fat loss does not compromise bone health in this model.
  • Future studies should explore adipose tissue loss effects in more severe obesity conditions.