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Relationship between serum total testosterone and prostate volume in aging men
Bo-Wen Xia1, Si-Cong Zhao1, Zong-Ping Chen1
1Department of Urology, Beijing Shijitan Hospital, Capital Medical University, 10th Tieyi Road, Haidian District, Beijing, 100038, China.
Scientific Reports
|July 9, 2021
Summary
In aging men, lower total testosterone levels are linked to larger prostate volumes and increased prostate growth over time. This suggests a significant relationship between testosterone and prostate health.
Area of Science:
- Urology
- Endocrinology
- Aging Research
Background:
- Testosterone levels naturally decrease with age.
- Prostate volume and benign prostatic hyperplasia prevalence increase with age.
Purpose of the Study:
- To investigate the correlation between serum testosterone levels and prostate volume in aging men.
- To examine the relationship between changes in prostate volume and testosterone levels over a 4-year period.
Main Methods:
- Analysis of clinical data from 416 healthy aging men.
- Longitudinal data collection over 4 years.
- Correlation analysis between prostate volume, testosterone levels, and obesity-related factors.
Main Results:
- Men with low testosterone had significantly larger prostate volumes compared to those with normal testosterone.
- Low testosterone was associated with higher levels of obesity-related factors (waist circumference, BMI, insulin).
- Testosterone level was negatively correlated with prostate volume, showing a linear decrease with increasing testosterone.
Conclusions:
- Testosterone levels are significantly associated with prostate volume in aging men.
- Low testosterone may contribute to increased prostate volume and growth.
- Further large-scale studies are warranted to confirm these findings.
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