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The Parathyroid Glands

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Related Experiment Video

Updated: Oct 29, 2025

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Parathyroid carcinoma detected within the thyroid.

Koki Otake¹, Yuichi Kondo¹, Kenji Tsukamoto¹

¹Department of Endocrinology and Diabetes, Okazaki City Hospital, Okazaki, Japan.

Nagoya Journal of Medical Science

|July 9, 2021

Summary

Parathyroid carcinoma, a rare cause of primary hyperparathyroidism, presents diagnostic challenges. This case highlights a rare asymptomatic parathyroid carcinoma mimicking an intrathyroidal tumor.

Keywords:

fine needle aspiration parathyroid carcinoma primary hyperparathyroidism

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Area of Science:

Endocrinology
Oncology
Surgical Pathology

Background:

Parathyroid carcinoma (PC) is a rare endocrine malignancy, comprising about 1% of primary hyperparathyroidism cases.
Preoperative differentiation of PC is crucial due to its potential for metastasis and local invasion.
Distinguishing PC preoperatively is challenging, particularly in asymptomatic patients or when tumors are near the thyroid gland.

Observation:

This report details an unusual case of parathyroid carcinoma presenting without any clinical symptoms.
Fine needle aspiration, a procedure generally contraindicated in suspected PC, was performed.
Preoperative evaluation suggested the tumor was located within the thyroid gland.

Findings:

The case demonstrates a rare instance of asymptomatic parathyroid carcinoma.
The diagnostic challenge was compounded by the tumor's intrathyroidal presentation.
The use of fine needle aspiration, despite contraindications, provided preoperative diagnostic information.

Implications:

This case underscores the importance of considering parathyroid carcinoma even in asymptomatic individuals.
It highlights the diagnostic difficulties in differentiating PC, especially with intrathyroidal or asymptomatic presentations.
Accurate preoperative diagnosis is vital for appropriate surgical management and patient outcomes in parathyroid cancer.