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Updated: Oct 29, 2025

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Current Progress in Investigating Mature T- and NK-Cell Lymphoma Gene Aberrations by Next-Generation Sequencing (NGS)

Lifen Zhu1, Shufang Xie1,2, Chen Yang1,3

  • 1Molecular diagnosis laboratory, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People's Republic of China.

Cancer Management and Research
|July 9, 2021
PubMed

Insights

Investigating gene mutations in mature natural killer/T-cell lymphoma (NKTCL) is crucial for developing new treatments. This review covers recent advances in NKTCL-related gene mutations and targeted therapies.

Area of Science:

  • Oncology
  • Hematology
  • Genetics

Background:

  • Mature natural killer/T-cell lymphoma (NKTCL) poses a severe threat to life.
  • Current therapeutic strategies require further investigation into NKTCL's regulatory biochemical processes.

Purpose of the Study:

  • To review recent advances in NKTCL-related gene mutations.
  • To highlight the role of genetic mutations in NKTCL pathogenesis and targeted therapy.

Main Methods:

  • Literature review of studies on NKTCL genetics.
  • Focus on next-generation sequencing (NGS) applications in lymphoma research.
  • Analysis of gene mutations identified in NKTCL.

Main Results:

  • Next-generation sequencing (NGS) is a key technique in lymphoma genetic research.
  • Genetic mutations are increasingly recognized as a critical area in lymphoma research.
  • Advances in understanding NKTCL-specific gene mutations are emerging.

Conclusions:

  • Further research into NKTCL-related gene mutations is essential for therapeutic progress.
  • Targeted therapies based on genetic findings show promise for NKTCL treatment.
  • Genetic mutation analysis is a vital research hotspot for NKTCL.
Keywords:
gene mutationmature T-and NK-cell lymphomanext generation sequencing

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