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Pericytes for Therapeutic Approaches to Ischemic Stroke
Lu Cao1, Yanbo Zhou1, Mengguang Chen1
1Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in Neuroscience
|July 9, 2021
Summary
Pericytes are crucial for brain blood vessel health and neurovascular regulation. Targeting these cells offers a promising new therapeutic strategy for treating ischemic stroke and related neurological disorders.
Area of Science:
- Neuroscience
- Cell Biology
- Vascular Biology
Background:
- Pericytes are multipotent cells integral to capillary structure and function.
- They play a key role in maintaining the blood-brain barrier (BBB) and regulating the neurovascular system.
- Pericyte dysfunction is implicated in neurological disorders, including ischemic stroke.
Purpose of the Study:
- To review the biology and functions of pericytes in the central nervous system.
- To elucidate the role of pericyte dysfunction in ischemic stroke pathogenesis.
- To discuss novel therapeutic strategies targeting pericytes for stroke treatment.
Main Methods:
- Literature review of pericyte biology and function.
- Analysis of studies on pericyte involvement in ischemic stroke.
- Synthesis of current research on pericyte-targeted therapies.
Main Results:
- Pericytes coordinate cellular communication within the neurovascular unit.
- Impaired pericyte function contributes to the development of ischemic stroke.
- Pericytes represent a viable therapeutic target for stroke intervention.
Conclusions:
- Understanding pericyte biology is essential for neurovascular health.
- Pericyte-targeted therapies hold significant potential for treating ischemic stroke.
- Further research is warranted to fully exploit pericytes as therapeutic targets.
